منابع مشابه
Psychiatric genetics, neurogenetics, and neurodegeneration
Neuropsychiatric disorders are common, complex, and severe disorders that affect the core of a person: their emotions, intellect, and ability to self-regulate. Millions of individuals worldwide suffer from these disorders; nevertheless, the factors that lead to the manifestation of symptoms are poorly understood. Neuropsychiatric disorders are characterized by heterogeneity, which means that di...
متن کاملDynamic mutations and psychiatric genetics
In the past 3 years, a novel class of pathogenic mutation has seized the attention of geneticists. Socalled 'dynamic mutations', caused by expanding trinucleotide repeats, are responsible for the pathogenesis of a growing list of disorders, including fragile X syndrome and Huntington's disease. In addition to a shared molecular mechanism, trinucleotide repeat diseases also share a number of cli...
متن کاملImaging Genetics and Psychiatric Disorders
Imaging genetics is an integrated research method that uses neuroimaging and genetics to assess the impact of genetic variation on brain function and structure. Imaging genetics is both a tool for the discovery of risk genes for psychiatric disorders and a strategy for characterizing the neural systems affected by risk gene variants to elucidate quantitative and mechanistic aspects of brain fun...
متن کاملPrinciples of Psychiatric Genetics
Genetic epidemiology The pioneering work of Böök, Sjögren, Angst, Perris, and others in Europe and Kallman, Heston, Rosenthal, Wender, and Kety in the United States firmly established the important role of genetic susceptibility factors in psychiatric disorders. Heston’s [1] original finding that adult offspring of hospitalized schizophrenic mothers had significantly higher rates of schizophren...
متن کاملReflections on the relationship between psychiatric genetics and psychiatric nosology.
Research advances in psychiatric genetics have raised expectations that genetic findings might lead to major breakthroughs in psychiatric nosology. The author reviews the plausibility of these claims. Four areas are addressed. First, it is argued that familial aggregation of a single putative psychiatric syndrome provides at best limited evidence for the validity of that syndrome. Second, both ...
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ژورنال
عنوان ژورنال: Journal of Medical Genetics
سال: 2004
ISSN: 1468-6244
DOI: 10.1136/jmg.2003.013375